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KMID : 0984920090110020119
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Journal of Skin Barrier Research
2009 Volume.11 No. 2 p.119 ~ p.119
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Sequential down-regulation of the skin barrier homeostasis in Otsuka Long-Evans Tokushima Fatty (OLETF) rat, type 2 diabetes animal model, with age
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Park Hwa-Young
Jung Min-Young
Chung Choon-Hee
Choi Eung-Ho
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Abstract
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Type 2 diabetes mellitus (DM) is a highly prevalent disease and induces many skin problems such as xerosis, pruritus, skin infection and delayed wound healing. However, little is known about the skin barrier state in diabetic patients. In this study, we investigated whether type 2 DM down-regulates skin barrier homeostasis relative to disease duration, and its
pathomechanism. We used Otsuka-Long-Evans-Tokushima-Fatty (OLETF) rats as an animal model of human type 2 diabetes and Long-Evans-Tokushima-Otsuka (LETO) rats as a control strain. At the ages of 15, 20, 30 and 45 weeks, metabolic changes and skin barrier homeostasis were evaluated. Body weight and hemoglobin A1c were significantly increased in OLETF rats with age. Glucose level was significantly higher in OLETF rats by intraperitoneal glucose
tolerance test. These results represent that OLETF rat is a useful animal model for human type 2 DM. In terms of skin barrier state, there was no difference between two groups until 20th week; however, OLETF rats demonstrated delayed barrier homeostasis from 30th week on. Skin barrier in the diabetes model was disrupted after 30th week, which was correlated with hemoglobin A1c level. OLETF rats also showed decreased epidermal lipid synthetic enzymes and antimicrobial peptide levels with age. In conclusion, type 2 DM down-regulates the skin barrier homeostasis
relative to disease duration, which becomes one of the main pathophysiologies underlying cutaneous problems of DM.
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KEYWORD
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Skin barrier homeostasis, Type 2 diabetes mellitus, Pathomechanism
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